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We have sampled and profiled a select subset of literature (n=68) to ensure enough variety in terms of coverage across studies in different regions around the globe, the type of wound, the type of study, year of publication, form of chitosan used, and study model

S. No. CountryIndicationScientific literatureYear of publicationForm of chitosan-based productType of studyStudy model
1Saudi ArabiaBurnsChitosan topical gel formulation in the management of burn wounds2009Gel / HydrogelResearch PublicationAnimal
2USBurnsChitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns▿2009Wound DressingResearch PublicationAnimal
3BrazilBurnsImprovement of dermal burn healing by combining sodium alginate/chitosan-based films and low level laser therapy2011FilmsResearch PublicationAnimal
4ChinaBurnsHydrogel sheets of chitosan, honey and gelatin as burn wound dressings2012Gel / HydrogelResearch PublicationAnimal
5Algeria BurnsEvaluation of healing activity of PVA/chitosan hydrogels on deep second degree burn: pharmacological and toxicological tests2013Gel / HydrogelResearch Publication Animal
6Brazil BurnsMicroparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment2014Other / MultipleResearch Publication Animal
7Taiwan General WoundsAssessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model2013Gel / Hydrogel Research Publication Animal
8TurkeyBurnsChitosan gel formulations containing egg yolk oil and epidermal growth factor for dermal burn treatment2015Gel / Hydrogel Research Publication Animal
9ChinaSpinal Cord injury NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury2015Other / MultipleResearch Publication Animal
10IranUlcersPotential application of nanochitosan film as a therapeutic agent against cutaneous leishmaniasis caused by L. major2015FilmsResearch PublicationAnimal
11IranBurnsChitosan gel-embedded moxifloxacin niosomes: An efficient antimicrobial hybrid system for burn infection2016Gel / Hydrogel Research PublicationAnimal
12ChinaBurnsOn-Demand Dissolvable Self-Healing Hydrogel Based on Carboxymethyl Chitosan and Cellulose Nanocrystal for Deep Partial Thickness Burn Wound Healing2018Gel / HydrogelResearch PublicationAnimal
13IranBurnsBromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models2019Other / MultipleResearch PublicationAnimal
14PakistanGeneral WoundsSilver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits2019Gel / Hydrogel Research Publication Animal
15ChinaOthers (Endometrial Injury)Controlled releasing of SDF-1α in chitosan-heparin hydrogel for endometrium injury healing in rat model2020Gel / HydrogelResearch PublicationAnimal
16IranBurnsEfficacy of topical platelet-rich plasma and chitosan co-administration on Candida albicans-infected partial thickness burn wound healing2020Gel / HydrogelResearch PublicationAnimal
17IranGeneral Wounds Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model2020Gel / HydrogelResearch PublicationAnimal
18BrazilUlcersA new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model2020MembranesResearch Publication Animal
19BrazilBurnsCarboxymethyl chitosan hydrogel formulations enhance the healing process in experimental partial-thickness (second-degree) burn wound healing2021Gel / Hydrogel Research PublicationAnimal
20China Others (Multiple Wounds) Effects of chitosan-collagen dressing on wound healing in vitro and in vivo assays2021Wound Dressing Research PublicationAnimal
21China BurnsChitosan degradation products promote healing of burn wounds of rat skin2022Other / Multiple Research PublicationAnimal
22ChinaSpinal Cord injuryChronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar2022Gel / HydrogelResearch PublicationAnimal
23ChileOthers (Multiple Wounds) Chitosan composite films. Biomedical applications2008FilmsResearch PublicationHuman
24Iran BurnsThe effect of chitosan-based gel on second degree burn wounds2016Gel / Hydrogel Research PublicationHuman
25IndiaTraumatic WoundsAssessing the Efficacy of Haemostatic Dressing Axiostat® In Trauma Care at a Tertiary Care Hospital in India: A Comparison with Conventional Cotton Gauze2016Wound DressingResearch Publication Human
26USBurnsThe use of a chitosan dressing with silver in the management of paediatric burn wounds: a pilot study2017Wound DressingResearch PublicationHuman
27Malaysia Traumatic WoundsEfficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds2018FilmsResearch Publication Human
28MalaysiaUlcersNano-colloidal silver and chitosan bioactive wound dressings in managing diabetic foot ulcers: case series2018Gel / Hydrogel Research Publication Human
29MexicoUlcersChitosan treatment for skin ulcers associated with diabetes2018FilmsResearch Publication Human
30MexicoUlcersEfficacy and safety of the combination of isosorbide dinitrate spray and chitosan gel for the treatment of diabetic foot ulcers: A double-blind, randomized, clinical trial2018Gel / Hydrogel Research Publication Human
31IranUlcersChitosan‑based biocompatible dressing for treatment of recalcitrant lesions of cutaneous leishmaniasis: A pilot clinical study2019FilmsResearch Publication Human
32Mexico UlcersCharacterization and efficacy of chitosan membranes in the treatment of skin ulcers2019MembranesResearch PublicationHuman
33SpainOthers (Dental Inflammation)Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial2020Gel / Hydrogel Research PublicationHuman
34ChinaBurnsStudy on scar repair and wound nursing of chitosan-based composite electrospun nanofibers in first aid of burn2021Other / Multiple Research PublicationHuman
35ThailandOthers (Skin Sebum) The Efficacy and Safety of Chitosan on Facial Skin Sebum2021Gel / Hydrogel Research PublicationHuman
36ChinaBurnsApplication and clinical efficacy of Sufu medical chitosan hydrogel dressing in radiation skin damage caused by radiotherapy for cervical cancer2022Gel / Hydrogel Research PublicationHuman
37ChinaOthers (Chronic refractory wounds) Clinical efficacy of chitosan-based hydrocolloid dressing in the treatment of chronic refractory wounds2022Wound Dressing Research PublicationHuman
38IndiaUlcersUse of Chitosan-based Dressings for the Management of a Chronic Lower Limb Ulcer: A Case Report2022Wound Dressing Research PublicationHuman
39ChinaBurnsClinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second‐degree burn wounds: A prospective, randomised, single‐blind, positive control clinical trial2023Wound Dressing Research PublicationHuman
40MalaysiaGeneral WoundsA Prospective Multicenter Randomized Controlled Trial to Evaluate the Efficacy of Chitosan Hydrogel Paste in Comparison to Commercial Hydroactive Gel as a Wound Bed Preparation2023Gel / Hydrogel Research PublicationHuman
41IndiaOthers (Multiple Wounds)Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing2011Gel / Hydrogel Research PublicationIn vitro
42PortugalOthers (Multiple Wounds)Chitosan drives anti-inflammatory macrophage polarisation and pro-inflammatory dendritic cell stimulation2012Other / MultipleResearch Publication In vitro
43South Korea Others (Drug resistant bacteria)Antimicrobial Action of Water-Soluble β-Chitosan against Clinical Multi-Drug Resistant Bacteria2015Other / MultipleResearch Publication In vitro
44IndiaInfected WoundCefuroxime conjugated chitosan hydrogel for treatment of wound infections2019Gel / HydrogelResearch Publication In vitro
45PakistanOthers (Multiple Wounds)Stimuli responsive biopolymer (chitosan) based blend hydrogels for wound healing application2019Gel / HydrogelResearch Publication In vitro
46IndiaOthers (Multiple Wounds)Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing2020FilmsResearch Publication In vitro
47IndiaOthers (Efficiency on L929 Fibroblast)Evaluation of curcumin-loaded chitosan nanoparticles for wound healing activity2023Other / MultipleResearch Publication In vitro
48USBurnsChitosan preparations for wounds and burns: antimicrobial and wound-healing effects2011Other / MultipleReview PublicationMixed
49IndiaOthers (Multiple Wounds)Biomaterials based on chitin and chitosan in wound dressing applications2011Other / MultipleReview PublicationMixed
50South KoreaTraumatic WoundsIn Situ Forming and Rutin-Releasing Chitosan Hydrogels As Injectable Dressings for Dermal Wound Healing2011Gel / Hydrogel Review PublicationMixed
51RomaniaOthers (Multiple Wounds) Chitosan as a starting material for wound healing applications2015Other / MultipleReview PublicationMixed
52IndiaOthers (Multiple Wounds) Chitosan Based Scaffolds and Their Applications in Wound Healing2016Other / MultipleReview PublicationMixed
53IndiaGeneral WoundsChitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings2018ScaffoldReview PublicationMixed
54ChinaOthers (Multiple Wounds) A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing2018Gel / HydrogelReview PublicationMixed
55IranGeneral Woundshttp://Chitosan/alginate hydrogels containing Alpha-tocopherol for wound healing in rat model2019Gel / Hydrogel Research PublicationMixed
56ChinaInfected WoundInjectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing2019Gel / Hydrogel Research PublicationMixed
57IndiaChitosan and gelatin-based electrospun fibers for bone tissue engineering2019ScaffoldReview PublicationMixed
58EgyptOthers (Multiple Wounds)Soft hydrogel based on modified chitosan containing P. granatum peel extract and its nano-forms: Multiparticulate study on chronic wounds treatment2019Gel / Hydrogel Research PublicationMixed
59ChinaTraumatic WoundsEnhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells2019Gel / HydrogelResearch PublicationMixed
60ChinaTraumatic WoundsPreparation of Antimicrobial Hyaluronic Acid/Quaternized Chitosan Hydrogels for the Promotion of Seawater-Immersion Wound Healing2019Gel / HydrogelResearch PublicationMixed
61ChinaTraumatic WoundsQuaternized chitosan-Matrigel-polyacrylamide hydrogels as wound dressing for wound repair and regeneration2019Gel / HydrogelResearch PublicationMixed
62ChinaGeneral WoundsModulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing2020Gel / HydrogelResearch PublicationMixed
63South AfricaOthers (Multiple Wounds)Chitosan and Cellulose-Based Hydrogels for Wound Management2020Gel / HydrogelReview PublicationMixed
64RomaniaInfected WoundPreparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review2021Other / MultipleReview PublicationMixed
65ChinaOthers (Multiple Wounds)Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications2021Gel / HydrogelReview PublicationMixed
66IndiaOthers (Progressive Wounds)Chitosan/Hyaluronic acid/Alginate and an assorted polymers loaded with honey, plant, and marine compounds for progressive wound healing-Know-how2021Other / MultipleReview PublicationMixed
67MexicoBurnsThe use of chitosan as a skin-regeneration agent in burns injuries: A review2022Other / MultipleReview PublicationMixed
68NigeriaOthers (Multiple Wounds)A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing2022Gel / HydrogelReview PublicationMixed